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Symbol
Name
ID
Ghr
growth hormone receptor
MGI:95708
Phenotype annotations related to endocrine/exocrine glands
Darker colors indicate more annotations
Human Phenotypes
Type II diabetes mellitus
Abnormality of the endocrine system
Decreased serum insulin-like growth factor 1
Anterior hypopituitarism
Delayed puberty
Delayed menarche
Disease(s) Associated with GHR
isolated growth hormone deficiency
Laron syndrome
type 2 diabetes mellitus

Mouse Phenotypes
decreased pancreatic beta cell proliferation
decreased pancreatic beta cell mass
small pancreatic islets
decreased pituitary gland weight
decreased prostate gland ventral lobe weight
abnormal seminal vesicle weight
decreased seminal vesicle weight
decreased corpora lutea number
decreased mature ovarian follicle number
impaired ovarian folliculogenesis
decreased testis weight
decreased insulin secretion
decreased activity of thyroid gland
abnormal ovary physiology
abnormal testes secretion
decreased testes secretion
Availability Mouse Genotype
Ghrtm1Jjk/Ghrtm1Jjk
Ghrtm1.1Dlr/Ghrtm1.1Dlr
Tg(Ins2-cre)25Mgn/0  (conditional)
Ghrtm1.1Dlr/Ghrtm1.1Dlr
Tg(Ins2-cre)23Herr/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory